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Myelodysplastic Syndromes

What Are Myelodysplastic Syndromes?

Our blood cells—which are responsible for blood clotting, transportation of oxygen, and immune defense against microorganisms that cause disease—are made in the marrow of our bones. Bone marrow is a spongy substance and houses the progenitor cells that give rise to our many different kinds of blood cells. In rare cases, these progenitor cells, do not develop properly and immature blood cells, also known as “blasts,” build up in the bone marrow and can be found in the blood. Their build-up reduces the number of healthy blood cells that are produced. These cases are known collectively as myelodysplastic syndromes (MDS) and are characterized by some combination of low blood cell counts (low red blood cells, low platelets, and/or low white blood cells). According to the World Health Organization, there are seven subtypes of MDS:

  • Refractory anemia (RA)
  • Refractory anemia with ringed sideroblasts (RARS)
  • Refractory cytopenia with multilineage dysplasia (RCMD)
  • Refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS)
  • Refractory anemia with excess blasts (RAEB)
  • Myelodysplastic syndrome, unclassified (MDS-U)
  • MDS associated with isolated del(5q)

What Causes Myelodysplastic Syndromes?

Myelodysplastic syndromes generally occur either because there has been damage to the bone marrow or because bone marrow cells possess a genetic abnormality, such as a deletion of genetic material from chromosome 5 in the case of MDS associated with isolated del(5q). Although an increased likelihood of developing a MDS is associated with the following factors, MDS often develops without an readily identifiable cause:

  • Aging
  • Personal history of chemotherapy
  • Exposure to tobacco smoke
  • Exposure to benzene
  • Exposure to heavy metals
  • Exposure to Agent Orange
  • Exposure to pesticides
  • Exposure to radiation

How Are Myelodysplastic Syndromes Detected?

Our specialists collect information regarding medical history, surgical history, social history, and family history; conduct laboratory testing; and review radiological studies to approach patient care in the most comprehensive and personalized manner.

The blood test normally used to assess for blood disorders is known as the “Complete Blood Count.” This test will allow your doctor to determine if you have an abnormal amount of any one or any combination of blood cell types. To investigate a suspicious finding further, your doctor may choose to order a flow cytometry or bone marrow biopsy. A flow cytometry is a cell counting technique used to gather more information about cells in the blood. A bone marrow biopsy is a tissue sampling technique used to determine the composition of the bone marrow and whether or not it is involved by an abnormality, such as a myelodysplastic syndrome.

Signs and Symptoms of Myelodysplastic Syndromes

The following may be indicative of a myelodysplastic syndrome but may also be indicative of other illnesses:

  • Abdominal bulging, discomfort, and/or pain
  • Bleeding
  • Bruising
  • Fatigue
  • General feeling of discomfort
  • Paleness
  • Persistent or recurrent fever
  • Red spotting of the skin
  • Shortness of breath

It is important you tell your doctor if you have any of these signs and symptoms, so he or she may determine their cause and plan treatment, if necessary.

How are Myelodysplastic Syndromes treated?

Treatment of myelodysplastic syndromes, depending on the type, may include observation, blood transfusions to improve blood cell counts, chemotherapy, and/or other therapeutic approaches. Treatments may be used individually or in combination based on your doctor’s recommendations. It’s important to discuss all of your treatment options with your doctor to help make the decision that best fits your needs. Some important factors to consider when deciding on a treatment plan include

  • Your age, health, and lifestyle.
  • Your specific type of myelodysplastic syndrome.
  • Any other serious health conditions you have.
  • Your feelings about the need to treat the myelodysplastic syndrome right away.
  • Your doctor’s opinion about if you need to treat the myelodysplastic syndrome right away.
  • The likelihood that treatment will help fight your myelodysplastic syndrome.
  • Possible side effects from each treatment method.

You may feel the need to make a quick decision, but it is very important to ask questions if there is anything you’re not sure about. It is very important for you and your doctor to communicate and work together to weigh the benefits of each treatment option against the possible side effects and to ultimately determine what treatment option is best for you.

NYCBS Clinical Trials in Myelodysplastic Syndromes

Clinical trials are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures. Clinical trials are one way to get state-of-the art treatment methods. Sometimes they may be the only way to get access to newer treatments. They are also the best way for doctors to learn how to better treat disease. If you would like to learn more about clinical trials that might be right for you, contact New York Cancer and Blood Specialist today at (855) 528-7322 to learn more.

The New York Cancer and Blood Specialists are a network of community treatment centers which provides programs and services, support groups, wellness care, and more to help patients. NYCBS has the experts to assist you.

If you need assistance, have questions, or would like to set up an appointment or consultation in regards to your diagnose or symptoms, please contact New York Cancer & Blood Specialists at (855) 528-7322 for more information and to speak with one of our trained specialists.